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Test Mnemonic DHEAS Dehydroepiandrosterone Sulfate (DHEA-S), Serum

Additional Codes

Mayo Test ID
DHES

Reporting Name

Dehydroepiandrosterone Sulfate, S

Useful For

Diagnosis and differential diagnosis of hyperandrogenism (in conjunction with measurements of other sex steroids)

 

An adjunct in the diagnosis of congenital adrenal hyperplasia

 

Diagnosis and differential diagnosis of premature adrenarche

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.8 mL

Forms: If not ordering electronically, complete, print, and send a General Request Form (T239) with the specimen (http://www.mayomedicallaboratories.com/it-mmfiles/general-request-form.pdf).


Specimen Minimum Volume

0.35 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  60 days

Reference Values

MALES

1-14 days: DHEA-S levels in newborns are very elevated at birth but will fall to prepubertal levels within a few days.

Tanner Stages* 

Mean

Age

Reference Range (mcg/dL)

Stage I

>14 days

<15-120

Stage II

11.5 years

<15-333

Stage III

13.6 years

<15-312

Stage IV

15.1 years

29-412

Stage V

18.0 years

89-457

*Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for boys at a median age of 11.5 (±) 2 years. For boys, there is no proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (adult) is usually reached by age 18.

18-29 years: 89-457 mcg/dL

30-39 years: 65-334 mcg/dL

40-49 years: 48-244 mcg/dL

50-59 years: 35-179 mcg/dL

≥60 years: 25-131 mcg/dL

 

FEMALES

1-14 days: DHEA-S levels in newborns are very elevated at birth but fall to prepubertal levels within a few days.

Tanner Stages* 

Mean

Age

Reference Range (mcg/dL)

Stage I

>14 days

16-96

Stage II

10.5 years

22-184

Stage III

11.6 years

<15-296

Stage IV

12.3 years

17-343

Stage V

14.5 years

44-332

*Puberty onset (transition from Tanner stage I to Tanner stage II) occurs for girls at a median age of 10.5 (±) 2 years. There is evidence that it may occur up to 1 year earlier in obese girls and in African American girls. Progression through Tanner stages is variable. Tanner stage V (adult) is usually reached by age 18.

18-29 years: 44-332 mcg/dL

30-39 years: 31-228 mcg/dL

40-49 years: 18-244 mcg/dL

50-59 years: <15-200 mcg/dL

≥60 years: <15-157 mcg/dL

Day(s) and Time(s) Performed

Monday through Friday; 5 a.m.-12 a.m., Saturday; 6 a.m.-6 p.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82627

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DHES Dehydroepiandrosterone Sulfate, S 2191-5

 

Result ID Test Result Name Result LOINC Value
DHES Dehydroepiandrosterone Sulfate, S 2191-5

Method Name

Automated Chemiluminescent Immunometric Assay