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Test Mnemonic DSG13 Desmoglein 1 (DSG1) and Desmoglein 3 (DSG3), IgG Antibodies, Serum

Reporting Name

Desmoglein 1 and 3, S

Useful For

Preferred screening test for patients suspected to have an autoimmune blistering disorder of the skin or mucous membranes (pemphigus)


As an aid in the diagnosis of pemphigus


Monitoring treatment response in patients with a confirmed diagnosis of pemphigus

Performing Laboratory

Mayo Medical Laboratories in Rochester

Specimen Type


Specimen Required


Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1 mL

Forms: If not ordering electronically, submit a Dermatopathology/Immunodermatology Request Form (Supply T060) with the specimen.

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 7 days
  Frozen  14 days
  Ambient  36 hours

Reference Values


<14.0 U (negative)

14.0-20.0 U (indeterminate)

>20.0 U (positive)



<9.0 U (negative)

9.0-20.0 U (indeterminate)

>20.0 U (positive)

Day(s) and Time(s) Performed

Once per week, Monday through Friday, day of testing determined by laboratory

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83516 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DSG13 Desmoglein 1 and 3, S 43309-4


Result ID Test Result Name Result LOINC Value
83680 DSG 1 43311-0
24027 DSG 3 43312-8

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)